![]() ![]() Fourteen patients were allocated into the active arm (2% PVP-I in vehicle solution twice daily) and seven patients were allocated into the vehicle-control solution arm twice daily, for a duration of 12 weeks in each arm. Those patients with prior treatment to the wart within the last 30 days were excluded, as were immunosuppressed and pregnant populations. Warts located in the following areas did not qualify patients for inclusion in the study: the eye area (including eyelids), lips, mouth cavity, nasal cavity, inner ear, palms of the hands (including periungual area), soles of the feet (including periungual area), or the anogenital area. Healthy individuals were deemed eligible for participation if they had at least one but not exceeding ten common warts. Informed consent was obtained from all participants or participants’ guardian if less than age of consent after explaining in detail the purpose and procedure of the treatment. The examiner determined the diagnosis of common warts clinically. Twenty-one patients aged 8 years and older were included in this single-center, randomized, double-blind, vehicle-controlled phase-2 proof-of-concept study. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964, as revised in 2013. The trial protocol and informed consent documents were approved by an Institutional Review Board experienced in both adult and pediatric studies. In this randomized, double-blind, vehicle-controlled study, we utilized a novel 2% PVP-I solution in a topical dimethyl sulfoxide vehicle twice daily for the treatment of common warts. ![]() Povidone–iodine kills microorganisms including bacteria, viruses, yeasts, molds, fungi and protozoa. The most commonly used iodophor is povidone–iodine. Primarily iodophors work by delivering active molecular iodine to target tissues through enhanced aqueous solubilization. Iodophor preparations are commonly used in all medical specialties for skin antisepsis prior to percutaneous procedures and surgery. Clinical evidence favoring one therapeutic route over another is limited. Treatment methods that are commonly employed include topical agents, intralesional injections, systemic agents, cryotherapy, laser, electrodessication and surgical excision, although common warts can be resistant to treatment. Many patients feel the condition is socially stigmatizing. Treatment is recommended for patients with extensive, spreading, or symptomatic warts. Verruca vulgaris typically occurs on the back of fingers or toes and on the knees, but they may occur anywhere on the skin or mucosal surface. Warts are prevalent in both childhood and adulthood and are spread by direct contact or autoinoculation. The common wart is most frequently caused by genotypes HPV-1, 2, 4, 27 and 57. ![]() There are more than 70 genotypes of HPV, and the genotypes are referenced by numbers. The cause of the condition is the human papilloma virus (HPV), which is a double-stranded, circular, supercoiled DNA virus enclosed in an icosahedral capsid and comprising 72 capsomers. It is a worldwide infection that affects 7–12% of the population. Verruca vulgaris, also known as common warts, are benign skin growths caused by a viral infection of the skin.
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